GLO1

Across TCGA pan-cancer cohorts, GLO1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GLO1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GLO1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GLO1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where GLO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GLO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.956	<.001	12	view →
THCA	Female	All	−0.334	<.001	10	view →
COAD	Female	II,III,IV	+0.927	<.001	8	view →
KICH	Female	All	−1.325	<.001	7	view →
BRCA	All	III,IV	+0.911	<.001	6	view →
LIHC	Male	All	+0.624	<.001	6	view →
KIRC	All	All	−0.234	.004	6	view →
CHOL	All	All	+1.057	<.001	5	view →
READ	Male	All	+0.913	.002	4	view →
BLCA	Male	All	+0.561	.010	4	view →
STAD	All	II,III,IV	+0.455	.010	2	view →
LUSC	All	All	+0.280	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GLO1–HNSC

Open the HNSC breakdown →