Across TCGA patient cohorts, GLMP mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLMP-associated genes across cancer lineages are ERK2, MEK1, and mTOR_pS2448. Each is linked with GLMP in more than 1 cancer types. Because this analysis shows association rather than direction, both GLMP-to-partner and partner-to-GLMP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLMP→partner) and Y-score (partner→GLMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.335	+3.584	<.001	.002	3	1
UCEC	MEK1 →	+0.524	+3.169	.003	.018	3	1
UCEC	mTOR_pS2448 →	-0.226	-3.584	.001	.002	3	1
UCEC	Shc_pY317 →	-0.222	-3.584	.002	.002	3	1
UCEC	ATM →	-1.015	-3.584	<.001	.002	2	2
UCEC	S6 →	-0.266	-2.459	.039	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

GLMP survival (RNA) · tumor vs normal (RNA) · all GLMP data types