GLIS3

Across TCGA patient cohorts, GLIS3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,383 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible GLIS3-associated genes across cancer lineages are GHDC, VWA8, and MLEC. Each is linked with GLIS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLIS3-to-partner and partner-to-GLIS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GLIS3 versus GHDC in CCRCC, with a Pearson correlation of -0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLIS3→partner) and Y-score (partner→GLIS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GHDC →	-0.549	-0.600	.008	.008	3	2
GBM	VWA8 →	-0.426	-0.424	.006	<.001	3	1
GBM	MLEC →	-0.427	-0.434	.007	<.001	3	1
GBM	HAND1 →	+0.104	+0.469	<.001	.008	3	1
GBM	MATN4 →	+0.535	+0.408	.005	.003	3	1
GBM	HECTD3 →	-0.467	-0.487	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,383 associations by consensus.

GLIS3 vs GHDC — CCRCC

Explore this scatter interactively →