GLIS3

Across TCGA patient cohorts, GLIS3 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLIS3-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and Cyclin-B1. Each is linked with GLIS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLIS3-to-partner and partner-to-GLIS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GLIS3-low versus GLIS3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLIS3→partner) and Y-score (partner→GLIS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.006	+2.178	.006	.035	3	3
UCEC	C-Raf →	+0.141	+2.169	.001	.003	3	3
UCEC	Cyclin-B1 →	+0.661	+2.115	<.001	<.001	3	3
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.600	+1.700	<.001	.038	3	2
COAD	CD31 →	+0.201	+3.000	.012	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.156	-2.087	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Caspase-7-cleavedD198 by GLIS3 expression — COAD

Explore this box plot interactively →