GLIS3

Across TCGA cell cohorts, GLIS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,301 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GLIS3-associated GO terms across cancer lineages are Positive regulation of cell-substrate junction organization, Positive regulation of blood pressure by epinephrine-norepinephrine, and Hepatocyte growth factor receptor signaling pathway. Each is linked with GLIS3 in more than 13 cancer types. Because this analysis shows association rather than direction, both GLIS3-to-partner and partner-to-GLIS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell-substrate junction organization grouped by GLIS3-low versus GLIS3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GLIS3→partner) and Y-score (partner→GLIS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of cell-substrate junction organization →	+0.175	+1.847	<.001	<.001	3	14
BONE	Positive regulation of blood pressure by epinephrine-norepinephrine →	+0.598	+2.224	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Hepatocyte growth factor receptor signaling pathway →	+0.231	+1.656	<.001	<.001	3	13
BONE	Positive regulation of supramolecular fiber organization →	+0.081	+1.714	<.001	<.001	3	12
LUNG_NSCLC_LUSC	PML body organization →	+0.222	+1.992	.003	.002	3	12
BONE	Positive regulation of focal adhesion assembly →	+0.239	+2.248	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,301 associations by consensus.

Positive regulation of cell-substrate junction organization by GLIS3 expression — BONE

Explore this box plot interactively →