GLIS3

Across TCGA cell cohorts, GLIS3 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLIS3-associated genes across cancer lineages are AVP, CHAT, and LCE1B. Each is linked with GLIS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLIS3-to-partner and partner-to-GLIS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by GLIS3-low versus GLIS3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLIS3→partner) and Y-score (partner→GLIS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	AVP →	+0.035	+4.781	<.001	.003	3	2
OESOPHAGUS	CHAT →	+0.110	+4.017	.004	.007	3	1
PANCREAS	LCE1B →	+0.029	+4.491	<.001	.003	3	1
STOMACH	DYNAP →	+0.119	+4.129	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	SOX14 →	+0.534	+4.209	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	RBMY1E →	+0.022	+4.357	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

AVP by GLIS3 expression — BREAST

Explore this box plot interactively →