GLIS2

Across TCGA cell cohorts, GLIS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,437 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLIS2-associated GO terms across cancer lineages are Regulation of hippo signaling, Regulation of substrate adhesion-dependent cell spreading, and Regulation of intracellular transport. Each is linked with GLIS2 in more than 12 cancer types. Because this analysis shows association rather than direction, both GLIS2-to-partner and partner-to-GLIS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hippo signaling grouped by GLIS2-low versus GLIS2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GLIS2→partner) and Y-score (partner→GLIS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of hippo signaling →	+0.101	+1.414	.006	.002	3	13
LUNG_SCLC	Regulation of substrate adhesion-dependent cell spreading →	+0.080	+1.014	.002	.004	3	12
BONE	Regulation of intracellular transport →	+0.059	+0.694	.001	.001	3	12
URINARY_TRACT	Golgi to plasma membrane transport →	+0.076	+1.471	.004	.001	3	12
LARGE_INTESTINE	Cellular response to environmental stimulus →	+0.040	+1.063	<.001	.006	3	11
URINARY_TRACT	Positive regulation of substrate adhesion-dependent cell spreading →	+0.131	+1.522	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,437 associations by consensus.

Regulation of hippo signaling by GLIS2 expression — LUNG_NSCLC_LUSC

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