GLIS2

Across TCGA cell cohorts, GLIS2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLIS2-associated genes across cancer lineages are COX6A2, TBC1D21, and OR1L6. Each is linked with GLIS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLIS2-to-partner and partner-to-GLIS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6A2 grouped by GLIS2-low versus GLIS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLIS2→partner) and Y-score (partner→GLIS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1
LARGE_INTESTINE	PRR23B →	+0.005	+4.217	<.001	.001	3	1
LARGE_INTESTINE	LCE1C →	+0.062	+3.684	.004	.006	3	1
LARGE_INTESTINE	CCER1 →	+0.013	+4.562	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

COX6A2 by GLIS2 expression — LARGE_INTESTINE

Explore this box plot interactively →