GLIS2-AS1

Across TCGA pan-cancer cohorts, GLIS2-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated GLIS2-AS1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GLIS2-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GLIS2-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, ACC, and HNSC are the cancer types where GLIS2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.866	0.755	<.001	87	view →
ACC	DFS	Median	All	0.287	0.609	<.001	63	view →
HNSC	OS	Tertile	IV	0.545	0.357	.001	48	view →
KIRP	DFS	Median	All	0.954	0.861	.001	47	view →
KIRC	OS	Quartile	All	0.842	0.712	<.001	44	view →
LGG	OS	Median	All	0.536	0.379	<.001	29	view →
UVM	DFS	Median	III,IV	0.854	0.463	.026	24	view →
CHOL	DFS	Quartile	II,III,IV	0.134	0.678	.004	21	view →
STAD	DFS	Median	III,IV	0.595	0.300	.009	20	view →
BLCA	OS	Quartile	IV	0.406	0.621	.006	14	view →
SKCM	DFS	Median	All	0.666	0.575	.007	12	view →
BRCA	OS	Tertile	All	0.941	0.898	.029	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GLIS2-AS1–LUAD (OS)

Open the LUAD breakdown →