GLIS1

Across TCGA patient cohorts, GLIS1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLIS1-associated genes across cancer lineages are TSC1, PCNA, and PKC-delta_pS664. Each is linked with GLIS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLIS1-to-partner and partner-to-GLIS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSC1 grouped by GLIS1-low versus GLIS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLIS1→partner) and Y-score (partner→GLIS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TSC1 →	-0.179	-1.415	.020	.045	3	2
UCEC	PCNA →	+0.178	+3.459	.041	.005	3	2
UCEC	PKC-delta_pS664 →	-0.180	-2.797	<.001	.003	2	3
SKCM	Dvl3 →	-0.155	-2.000	.048	.029	3	1
UCEC	14-3-3_beta →	-0.087	-2.088	.032	.016	3	1
UCEC	eEF2 →	+0.428	+1.906	.002	.016	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

TSC1 by GLIS1 expression — SKCM

Explore this box plot interactively →