GLIS1

Across TCGA cell cohorts, GLIS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,994 significant associations in total. CNS shows the largest number of these associations.

The most reproducible GLIS1-associated GO terms across cancer lineages are Positive regulation of actin filament bundle assembly, Positive regulation of cell-substrate junction organization, and Collagen fibril organization. Each is linked with GLIS1 in more than 10 cancer types. Because this analysis shows association rather than direction, both GLIS1-to-partner and partner-to-GLIS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of actin filament bundle assembly grouped by GLIS1-low versus GLIS1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GLIS1→partner) and Y-score (partner→GLIS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of actin filament bundle assembly →	+0.169	+1.651	<.001	<.001	3	11
BONE	Positive regulation of cell-substrate junction organization →	+0.136	+1.390	.004	.002	3	10
BONE	Collagen fibril organization →	+0.276	+1.257	<.001	<.001	3	10
OVARY	Trophoblast cell migration →	+0.288	+0.465	<.001	.001	3	10
SOFT_TISSUE	Regulation of actomyosin structure organization →	+0.060	+0.728	<.001	.006	3	10
LIVER	Regulation of glutamate uptake involved in transmission of nerve impulse →	+0.161	+0.969	.002	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,994 associations by consensus.

Positive regulation of actin filament bundle assembly by GLIS1 expression — BONE

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