GLIS1

Across TCGA cell cohorts, GLIS1 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLIS1-associated genes across cancer lineages are BANF2, MYL10, and GHRHR. Each is linked with GLIS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLIS1-to-partner and partner-to-GLIS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BANF2 grouped by GLIS1-low versus GLIS1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLIS1→partner) and Y-score (partner→GLIS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BANF2 →	+0.096	+5.643	<.001	.002	3	1
LUNG_SCLC	MYL10 →	+0.059	+3.523	.003	.008	3	1
BLOOD_Leukemia	GHRHR →	+0.358	+3.705	<.001	.007	3	1
BLOOD_Leukemia	HRG →	+0.414	+3.855	<.001	.007	3	1
BLOOD_Leukemia	MMP20 →	+0.041	+3.705	.003	.007	3	1
BLOOD_Leukemia	GC →	+0.157	+4.691	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

BANF2 by GLIS1 expression — BLOOD_Lymphoma

Explore this box plot interactively →