GLIPR1

Across TCGA patient cohorts, GLIPR1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLIPR1-associated genes across cancer lineages are MEK1, EGFR_pY1068, and GSK-3_pS9. Each is linked with GLIPR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLIPR1-to-partner and partner-to-GLIPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GLIPR1-low versus GLIPR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLIPR1→partner) and Y-score (partner→GLIPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.460	+2.807	.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.217	-1.874	.024	.049	3	1
UCEC	GSK-3_pS9 →	-0.309	-1.874	.046	.049	3	1
UCEC	JNK2 →	+0.232	+2.469	.002	.010	3	1
UCEC	Notch1 →	+0.140	+2.087	.009	.005	3	1
UCEC	p62 Lck ligand →	+0.390	+1.594	.001	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MEK1 by GLIPR1 expression — UCEC

Explore this box plot interactively →