GLI4

Across TCGA patient cohorts, GLI4 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,940 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GLI4-associated proteins across cancer lineages are PUF60, PYCR3, and SMC1A. Each is linked with GLI4 in more than 6 cancer types. Because this analysis shows association rather than direction, both GLI4-to-partner and partner-to-GLI4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GLI4 versus PUF60 in OV, with a Pearson correlation of 0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI4→partner) and Y-score (partner→GLI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PUF60 →	+0.421	+0.655	.002	<.001	3	7
BRCA	PYCR3 →	+0.518	+0.831	<.001	<.001	3	5
GBM	SMC1A →	+0.326	+0.393	.001	<.001	3	5
UCEC	DHX9 →	+0.197	+0.576	<.001	<.001	3	5
PDAC	DPY30 →	+0.472	+0.403	.002	<.001	2	6
HNSC	HNRNPR →	+0.251	+0.625	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,940 associations by consensus.

GLI4 vs PUF60 — OV

Explore this scatter interactively →