GLI4

Across TCGA patient cohorts, GLI4 mutation is significantly associated with the RNA expression of many other genes, with 164 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLI4-associated genes across cancer lineages are RNU1-57P, LINC01867, and RN7SL73P. Each is linked with GLI4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLI4-to-partner and partner-to-GLI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-57P grouped by GLI4-low versus GLI4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI4→partner) and Y-score (partner→GLI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU1-57P →	+0.180	+4.470	<.001	.004	3	2
BLCA	LINC01867 →	+0.041	+5.229	<.001	.002	3	2
UCEC	RN7SL73P →	+0.172	+2.734	.001	.008	3	2
UCEC	MIR6803 →	+0.276	+5.478	<.001	<.001	3	2
SKCM	RNU1-19P →	+0.430	+5.682	<.001	<.001	3	2
LUAD	RNU6-966P →	+0.283	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 164 associations by consensus.

RNU1-57P by GLI4 expression — UCEC

Explore this box plot interactively →