GLI4

Across TCGA patient cohorts, GLI4 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible GLI4-associated genes across cancer lineages are Monocytes, CD4+ Tcm, and CD8+ Tem. Each is linked with GLI4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLI4-to-partner and partner-to-GLI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocytes grouped by GLI4-low versus GLI4-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI4→partner) and Y-score (partner→GLI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	Monocytes →	+0.014	+5.305	.007	.048	3	1
HNSC	CD4+ Tcm →	+0.015	+6.468	<.001	.001	3	1
UCEC	CD8+ Tem →	+0.004	+4.896	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Monocytes by GLI4 expression — LIHC

Explore this box plot interactively →