GLI4

Across TCGA cell cohorts, GLI4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,374 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GLI4-associated GO terms across cancer lineages are Cilium movement involved in cell motility, Cilium-dependent cell motility, and Cilium or flagellum-dependent cell motility. Each is linked with GLI4 in more than 15 cancer types. Because this analysis shows association rather than direction, both GLI4-to-partner and partner-to-GLI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cilium movement involved in cell motility grouped by GLI4-low versus GLI4-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI4→partner) and Y-score (partner→GLI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Cilium movement involved in cell motility →	-0.106	-1.159	<.001	<.001	3	16
URINARY_TRACT	Cilium-dependent cell motility →	-0.097	-1.159	<.001	<.001	3	15
URINARY_TRACT	Cilium or flagellum-dependent cell motility →	-0.097	-1.159	<.001	<.001	3	15
BONE	Pre-mRNA catabolic process →	+0.221	+1.588	.002	<.001	3	14
BONE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.153	+1.091	.001	.006	3	14
URINARY_TRACT	mRNA splice site recognition →	+0.113	+1.129	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,374 associations by consensus.

Cilium movement involved in cell motility by GLI4 expression — URINARY_TRACT

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