GLI4

Across TCGA cell cohorts, GLI4 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GLI4-associated genes across cancer lineages are CDH20, OR5C1, and PABPN1L. Each is linked with GLI4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLI4-to-partner and partner-to-GLI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH20 grouped by GLI4-low versus GLI4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI4→partner) and Y-score (partner→GLI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDH20 →	+0.153	+4.392	<.001	.004	3	1
LARGE_INTESTINE	OR5C1 →	+0.035	+3.793	.005	.007	3	1
LARGE_INTESTINE	PABPN1L →	+0.049	+4.054	<.001	.004	3	1
LARGE_INTESTINE	DEFA1 →	+0.242	+3.920	.002	.005	3	1
BLOOD_Lymphoma	GJA8 →	+0.027	+5.129	<.001	<.001	3	1
BLOOD_Lymphoma	GHSR →	+0.201	+4.765	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

CDH20 by GLI4 expression — LARGE_INTESTINE

Explore this box plot interactively →