GLI3

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, GLI3 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,260 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GLI3-associated proteins across cancer lineages are TIMP2, COL1A1, and COL3A1. Each is linked with GLI3 in more than 8 cancer types. Because this analysis shows association rather than direction, both GLI3-to-partner and partner-to-GLI3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GLI3 versus TIMP2 in BRCA, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI3→partner) and Y-score (partner→GLI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCATIMP2 →+0.739+1.023<.001<.00139
COADCOL1A1 →+1.080+0.645<.001<.00139
HNSCCOL3A1 →+0.709+0.961<.001<.00139
BRCACOL5A1 →+0.978+1.120<.001<.00139
UCECGLI3_S445 →+1.616+2.020<.001<.00139
OVPCOLCE →+0.796+1.046<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 16,260 associations by consensus.

GLI3 vs TIMP2 — BRCA

Per-sample scatter of GLI3 vs TIMP2 in BRCA (Pearson r = 0.37).

Explore this scatter interactively →

Exploration