GLI3

Across TCGA patient cohorts, GLI3 protein abundance is significantly associated with the RNA expression of many other genes, with 8,752 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GLI3-associated genes across cancer lineages are ADAMTS12, PLXNB2, and MEDAG. Each is linked with GLI3 in more than 3 cancer types. Because this analysis shows association rather than direction, both GLI3-to-partner and partner-to-GLI3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GLI3 versus ADAMTS12 in LSCC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI3→partner) and Y-score (partner→GLI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADAMTS12 →	+0.851	+0.285	<.001	.003	3	4
OV	PLXNB2 →	+1.927	+1.865	.009	.003	3	4
UCEC	MEDAG →	+1.500	+0.811	<.001	<.001	3	3
LSCC	PLAT →	+1.401	+0.413	<.001	<.001	3	3
OV	NID1 →	+3.150	+1.680	.002	.003	3	3
UCEC	CNRIP1 →	+0.970	+0.714	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,752 associations by consensus.

GLI3 vs ADAMTS12 — LSCC

Explore this scatter interactively →