GLI3

Across TCGA patient cohorts, GLI3 mutation is significantly associated with the RNA expression of many other genes, with 7,636 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLI3-associated genes across cancer lineages are TAF9, LARP1B, and MRPS5. Each is linked with GLI3 in more than 4 cancer types. Because this analysis shows association rather than direction, both GLI3-to-partner and partner-to-GLI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF9 grouped by GLI3-low versus GLI3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI3→partner) and Y-score (partner→GLI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAF9 →	+0.569	+1.634	<.001	<.001	3	5
UCEC	LARP1B →	+0.387	+1.494	<.001	<.001	3	5
STAD	MRPS5 →	+0.316	+1.886	<.001	<.001	3	5
UCEC	RMI1 →	+0.353	+1.584	.002	<.001	3	4
UCEC	CCDC89 →	-0.508	-1.257	<.001	<.001	3	4
UCEC	NPM1 →	+0.346	+1.506	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,636 associations by consensus.

TAF9 by GLI3 expression — UCEC

Explore this box plot interactively →