GLI3

Across TCGA cell cohorts, GLI3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,782 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GLI3-associated GO terms across cancer lineages are Negative T cell selection, Negative thymic T cell selection, and Nuclear export. Each is linked with GLI3 in more than 12 cancer types. Because this analysis shows association rather than direction, both GLI3-to-partner and partner-to-GLI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative T cell selection grouped by GLI3-low versus GLI3-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI3→partner) and Y-score (partner→GLI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative T cell selection →	+1.817	+1.659	<.001	<.001	3	13
SKIN	Negative thymic T cell selection →	+1.675	+1.631	<.001	<.001	3	12
OESOPHAGUS	Nuclear export →	+0.097	+1.466	.002	.004	3	12
SKIN	Positive regulation of chromosome organization →	+0.072	+1.647	<.001	<.001	3	12
SKIN	Regulation of smoothened signaling pathway →	+0.031	+1.032	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Protein localization to nucleus →	+0.062	+1.220	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,782 associations by consensus.

Negative T cell selection by GLI3 expression — SKIN

Explore this box plot interactively →