GLI3

Across TCGA cell cohorts, GLI3 mutation is significantly associated with the RNA expression of many other genes, with 342 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GLI3-associated genes across cancer lineages are SOX14, C9orf92, and SHISA8. Each is linked with GLI3 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLI3-to-partner and partner-to-GLI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOX14 grouped by GLI3-low versus GLI3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI3→partner) and Y-score (partner→GLI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SOX14 →	+0.736	+3.882	<.001	.004	3	2
LUNG_SCLC	C9orf92 →	+0.609	+4.523	<.001	.003	3	2
CNS	SHISA8 →	+0.079	+3.247	.001	.001	3	2
LUNG_NSCLC_LUAD	NOL6 →	-0.591	-3.663	.001	<.001	3	2
LUNG_NSCLC_LUAD	ZNF124 →	-0.533	-2.548	.003	.006	3	2
LUNG_NSCLC_LUAD	ANAPC7 →	-0.426	-3.517	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 342 associations by consensus.

SOX14 by GLI3 expression — SOFT_TISSUE

Explore this box plot interactively →