GLE1

Across TCGA patient cohorts, GLE1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLE1-associated genes across cancer lineages are GATA6, MSH6, and ATM. Each is linked with GLE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLE1-to-partner and partner-to-GLE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by GLE1-low versus GLE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLE1→partner) and Y-score (partner→GLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.167	-3.155	.010	.018	3	2
UCEC	MSH6 →	-0.450	-2.999	.001	.035	3	2
UCEC	ATM →	-0.593	-1.700	.002	.044	3	2
UCEC	eEF2 →	+0.470	+2.999	.001	.035	3	1
UCEC	EGFR_pY1068 →	-0.299	-2.459	.005	.019	3	1
UCEC	GAPDH →	+0.503	+2.222	.027	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

GATA6 by GLE1 expression — UCEC

Explore this box plot interactively →