GLE1

Across TCGA cell cohorts, GLE1 mutation is significantly associated with the RNA expression of many other genes, with 107 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GLE1-associated genes across cancer lineages are OTOR, TERB2, and A4GNT. Each is linked with GLE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLE1-to-partner and partner-to-GLE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOR grouped by GLE1-low versus GLE1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLE1→partner) and Y-score (partner→GLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OTOR →	+0.030	+5.087	<.001	.004	3	1
URINARY_TRACT	TERB2 →	+0.050	+5.087	<.001	.004	3	1
LARGE_INTESTINE	A4GNT →	+0.100	+4.129	<.001	.001	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR52H1 →	+0.025	+3.347	<.001	.005	3	1
LARGE_INTESTINE	WNT8A →	+0.018	+3.632	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

OTOR by GLE1 expression — URINARY_TRACT

Explore this box plot interactively →