Across TCGA patient cohorts, GLDN mutation is significantly associated with the RNA expression of many other genes, with 709 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLDN-associated genes across cancer lineages are ACOT7, MIR147A, and AKIP1. Each is linked with GLDN in more than 2 cancer types. Because this analysis shows association rather than direction, both GLDN-to-partner and partner-to-GLDN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLDN→partner) and Y-score (partner→GLDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ACOT7 →	+0.485	+1.945	.008	.003	3	3
COAD	MIR147A →	+0.617	+4.893	<.001	.005	3	2
UCEC	AKIP1 →	+0.441	+3.332	.003	.005	3	2
UCEC	ATPAF2 →	+0.438	+3.513	<.001	.002	3	2
UCEC	RNF126 →	+0.565	+2.354	<.001	.003	2	3
UCEC	WDR62 →	+0.641	+3.480	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 709 associations by consensus.

Exploration

GLDN survival (RNA) · tumor vs normal (RNA) · all GLDN data types