Across TCGA patient cohorts, GLDN mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLDN-associated genes across cancer lineages are NF2, Annexin-1, and Caspase-7-cleavedD198. Each is linked with GLDN in more than 1 cancer types. Because this analysis shows association rather than direction, both GLDN-to-partner and partner-to-GLDN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLDN→partner) and Y-score (partner→GLDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.324	+3.169	.001	.019	3	2
UCEC	Annexin-1 →	+0.634	+2.341	.009	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.722	+3.189	.008	.010	3	2
UCEC	EGFR_pY1068 →	-0.323	-3.169	.005	.018	3	1
UCEC	eIF4E →	+0.221	+3.013	.024	.018	3	1
UCEC	Fibronectin →	-0.316	-2.449	.040	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

GLDN survival (RNA) · tumor vs normal (RNA) · all GLDN data types