Across TCGA cell cohorts, GLDN mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GLDN-associated genes across cancer lineages are OR10R2, MYL10, and LGI1. Each is linked with GLDN in more than 1 cancer types. Because this analysis shows association rather than direction, both GLDN-to-partner and partner-to-GLDN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLDN→partner) and Y-score (partner→GLDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10R2 →	+1.499	+3.551	<.001	.009	3	2
BLOOD_Leukemia	MYL10 →	+0.022	+4.984	<.001	.002	3	1
BLOOD_Leukemia	LGI1 →	+0.079	+5.124	<.001	<.001	3	1
BLOOD_Leukemia	MMP27 →	+0.015	+4.384	<.001	.006	3	1
BLOOD_Leukemia	HCN4 →	+0.063	+3.855	<.001	.007	3	1
BLOOD_Leukemia	AWAT2 →	+0.012	+3.705	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

GLDN survival (RNA) · tumor vs normal (RNA) · all GLDN data types