GLDC

Across TCGA pan-cancer cohorts, GLDC mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GLDC data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher GLDC mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GLDC expression acts as an unfavorable survival marker, although some lineages such as GBM and OV show a favorable association.

GBM, UCEC, and OV are the cancer types where GLDC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.958	0.762	.001	21	view →
UCEC	OS	Median	All	0.841	0.982	.005	16	view →
OV	DFS	Quartile	All	0.923	0.513	.044	8	view →
LSCC	DFS	Quartile	All	0.911	0.635	.011	8	view →
LUAD	OS	Tertile	II,III,IV	0.262	0.792	.001	8	view →
CCRCC	OS	Tertile	All	1.000	0.929	.036	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GLDC–GBM (OS)

Open the GBM breakdown →