GLCE

Across TCGA patient cohorts, GLCE mutation is significantly associated with the RNA expression of many other genes, with 2,068 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLCE-associated genes across cancer lineages are LRRC37A13P, SRCIN1, and RN7SL22P. Each is linked with GLCE in more than 2 cancer types. Because this analysis shows association rather than direction, both GLCE-to-partner and partner-to-GLCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC37A13P grouped by GLCE-low versus GLCE-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLCE→partner) and Y-score (partner→GLCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LRRC37A13P →	+0.212	+4.363	<.001	.007	3	3
UCEC	SRCIN1 →	-0.605	-2.079	.001	.005	3	2
SKCM	RN7SL22P →	+0.073	+3.095	<.001	.007	3	2
UCEC	SBF1 →	+0.615	+2.917	<.001	<.001	3	2
UCEC	LMF2 →	+0.391	+3.210	.003	<.001	3	2
UCEC	TXN2 →	+0.268	+2.346	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,068 associations by consensus.

LRRC37A13P by GLCE expression — BLCA

Explore this box plot interactively →