GLCE

Across TCGA patient cohorts, GLCE mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLCE-associated genes across cancer lineages are mTOR_pS2448, PCNA, and TSC1. Each is linked with GLCE in more than 1 cancer types. Because this analysis shows association rather than direction, both GLCE-to-partner and partner-to-GLCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by GLCE-low versus GLCE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLCE→partner) and Y-score (partner→GLCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.119	-2.446	.029	.018	3	2
UCEC	PCNA →	+0.253	+2.736	.001	<.001	3	2
UCEC	TSC1 →	-0.175	-1.960	.005	.029	3	2
UCEC	Caspase-8 →	-0.241	-2.247	.009	.001	3	2
UCEC	eIF4E →	+0.170	+3.183	.027	.009	3	1
UCEC	IGFBP2 →	-0.750	-2.000	.001	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

mTOR_pS2448 by GLCE expression — UCEC

Explore this box plot interactively →