GLCE

Across TCGA cell cohorts, GLCE mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLCE-associated genes across cancer lineages are C11orf53, KRTAP10-8, and DEFB133. Each is linked with GLCE in more than 1 cancer types. Because this analysis shows association rather than direction, both GLCE-to-partner and partner-to-GLCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C11orf53 grouped by GLCE-low versus GLCE-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLCE→partner) and Y-score (partner→GLCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C11orf53 →	+0.128	+4.315	.003	.006	3	1
CNS	KRTAP10-8 →	+0.025	+5.357	<.001	.001	3	1
CNS	DEFB133 →	+0.035	+5.357	<.001	.001	3	1
CNS	OR13C2 →	+0.009	+4.754	<.001	.005	3	1
SKIN	UGT2B10 →	+0.006	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	OR6N1 →	+0.225	+4.867	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

C11orf53 by GLCE expression — CNS

Explore this box plot interactively →