GLB1L2

Across TCGA cell cohorts, GLB1L2 mutation is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLB1L2-associated genes across cancer lineages are REG1B, PLA2G3, and TMEM9. Each is linked with GLB1L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLB1L2-to-partner and partner-to-GLB1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by GLB1L2-low versus GLB1L2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLB1L2→partner) and Y-score (partner→GLB1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	2
LARGE_INTESTINE	PLA2G3 →	+1.152	+3.537	<.001	.001	3	1
LARGE_INTESTINE	TMEM9 →	+0.595	+3.064	.007	.009	3	1
LARGE_INTESTINE	LGALS12 →	+0.079	+2.410	.007	.006	3	1
LARGE_INTESTINE	MYG1 →	+0.361	+3.364	.001	.002	3	1
LARGE_INTESTINE	IMPA2 →	+1.129	+3.082	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

REG1B by GLB1L2 expression — BREAST

Explore this box plot interactively →