GLB1L

Across TCGA cell cohorts, GLB1L mutation is significantly associated with the drug of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLB1L-associated genes across cancer lineages are VSP34_8731, 50869, and KRAS (G12C) Inhibitor-12. Each is linked with GLB1L in more than 1 cancer types. Because this analysis shows association rather than direction, both GLB1L-to-partner and partner-to-GLB1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VSP34_8731 grouped by GLB1L-low versus GLB1L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLB1L→partner) and Y-score (partner→GLB1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VSP34_8731 →	+0.430	+2.710	.032	.027	3	1
LARGE_INTESTINE	50869 →	+0.430	+2.649	.042	.046	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.510	+2.646	.041	.047	3	1
LARGE_INTESTINE	CDK9_5576 →	+0.548	+2.649	.036	.046	2	1
LARGE_INTESTINE	123829 →	+0.639	+2.649	.028	.046	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

VSP34_8731 by GLB1L expression — LARGE_INTESTINE

Explore this box plot interactively →