GLB1

Across TCGA patient cohorts, GLB1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,665 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GLB1-associated genes across cancer lineages are SRPX2, POLR3C, and RPL18. Each is linked with GLB1 in more than 4 cancer types. Because this analysis shows association rather than direction, both GLB1-to-partner and partner-to-GLB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GLB1 versus SRPX2 in COAD, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLB1→partner) and Y-score (partner→GLB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SRPX2 →	+1.180	+0.314	<.001	.001	3	5
BRCA	POLR3C →	-0.515	-0.329	<.001	<.001	3	4
HNSC	RPL18 →	-1.186	-0.207	.001	.008	3	4
GBM	GNRHR2 →	-0.276	-0.262	.003	.001	3	4
CCRCC	HOXD3 →	-0.567	-0.200	<.001	.006	3	3
HNSC	MCM5 →	-0.701	-0.171	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,665 associations by consensus.

GLB1 vs SRPX2 — COAD

Explore this scatter interactively →