GLB1

Across TCGA patient cohorts, GLB1 mutation is significantly associated with the RNA expression of many other genes, with 1,372 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLB1-associated genes across cancer lineages are ANKRD33B-AS1, RNA5SP415, and RPL22P10. Each is linked with GLB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLB1-to-partner and partner-to-GLB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD33B-AS1 grouped by GLB1-low versus GLB1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLB1→partner) and Y-score (partner→GLB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ANKRD33B-AS1 →	+0.198	+3.513	<.001	.008	3	3
UCEC	RNA5SP415 →	+0.483	+1.986	<.001	.007	3	3
BRCA	RPL22P10 →	+0.210	+4.147	<.001	.002	3	3
UCEC	RNA5SP412 →	+0.367	+1.774	.009	.009	3	3
UCEC	RN7SKP286 →	+0.036	+3.668	<.001	.009	3	3
SCLC	SMIM21 →	+0.049	+5.189	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,372 associations by consensus.

ANKRD33B-AS1 by GLB1 expression — BRCA

Explore this box plot interactively →