GLB1

Across TCGA cell cohorts, GLB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,244 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GLB1-associated GO terms across cancer lineages are Response to Thyroglobulin triiodothyronine, Ganglioside catabolic process, and Regulation of protein exit from endoplasmic reticulum. Each is linked with GLB1 in more than 15 cancer types. Because this analysis shows association rather than direction, both GLB1-to-partner and partner-to-GLB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to Thyroglobulin triiodothyronine grouped by GLB1-low versus GLB1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GLB1→partner) and Y-score (partner→GLB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Response to Thyroglobulin triiodothyronine →	+0.284	+0.991	<.001	<.001	3	16
BONE	Ganglioside catabolic process →	+0.232	+0.964	<.001	<.001	3	15
BONE	Regulation of protein exit from endoplasmic reticulum →	+0.173	+1.267	<.001	<.001	3	15
BONE	Endoplasmic reticulum mannose trimming →	+0.116	+0.784	<.001	<.001	3	14
BONE	Positive regulation of retrograde protein transport, ER to cytosol →	+0.130	+0.818	<.001	<.001	3	14
SOFT_TISSUE	Amyloid-beta clearance by transcytosis →	+0.168	+0.899	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,244 associations by consensus.

Response to Thyroglobulin triiodothyronine by GLB1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →