GLB1

Across TCGA cell cohorts, GLB1 mutation is significantly associated with the RNA expression of many other genes, with 965 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLB1-associated genes across cancer lineages are ADAM7, CLDN34, and HMGXB4. Each is linked with GLB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLB1-to-partner and partner-to-GLB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by GLB1-low versus GLB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLB1→partner) and Y-score (partner→GLB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM7 →	+0.002	+2.345	<.001	.007	3	2
BLOOD_Leukemia	CLDN34 →	+0.054	+4.984	<.001	.002	3	1
LARGE_INTESTINE	HMGXB4 →	+0.607	+2.389	.001	.006	3	1
LARGE_INTESTINE	MTMR3 →	+0.719	+3.502	.001	.001	3	1
LARGE_INTESTINE	PLTP →	-2.030	-3.416	.002	.002	3	1
LARGE_INTESTINE	FNDC3A →	+0.499	+3.064	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 965 associations by consensus.

ADAM7 by GLB1 expression — LARGE_INTESTINE

Explore this box plot interactively →