GLA

Across TCGA pan-cancer cohorts, GLA mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GLA data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GLA mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GLA expression acts as an unfavorable survival marker.

HNSC, CCRCC, and UCEC are the cancer types where GLA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.627	0.880	.009	16	view →
CCRCC	DFS	Median	All	0.520	0.929	.004	16	view →
UCEC	OS	Quartile	II,III,IV	0.369	1.000	.032	10	view →
LSCC	DFS	Quartile	All	0.407	1.000	.002	8	view →
OV	DFS	Median	All	0.874	1.000	.047	4	view →
GBM	OS	Quartile	All	0.855	0.916	.026	3	view →
PDAC	OS	Median	IV	0.540	0.951	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GLA–HNSC (OS)

Open the HNSC breakdown →