GLA

Across TCGA cell cohorts, GLA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,705 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GLA-associated GO terms across cancer lineages are Negative regulation of oxidoreductase activity, Regulation of nitric-oxide synthase activity, and Glycoside metabolic process. Each is linked with GLA in more than 19 cancer types. Because this analysis shows association rather than direction, both GLA-to-partner and partner-to-GLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of oxidoreductase activity grouped by GLA-low versus GLA-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GLA→partner) and Y-score (partner→GLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of oxidoreductase activity →	+0.184	+1.492	<.001	<.001	3	20
LIVER	Regulation of nitric-oxide synthase activity →	+0.313	+1.854	.001	<.001	3	18
LUNG_NSCLC_LUSC	Glycoside metabolic process →	+0.329	+1.795	<.001	.003	3	11
BLOOD_Myeloma	Chromosome segregation →	+0.092	+1.066	.001	.001	3	9
LUNG_SCLC	Heme metabolic process →	+0.105	+0.971	<.001	<.001	3	9
SKIN	Sulfur compound transport →	+0.084	+0.933	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,705 associations by consensus.

Negative regulation of oxidoreductase activity by GLA expression — LIVER

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