GLA

Across TCGA cell cohorts, GLA mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLA-associated genes across cancer lineages are PCDH11Y, BPIFA1, and PRAMEF20. Each is linked with GLA in more than 1 cancer types. Because this analysis shows association rather than direction, both GLA-to-partner and partner-to-GLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDH11Y grouped by GLA-low versus GLA-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLA→partner) and Y-score (partner→GLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PCDH11Y →	+0.016	+5.087	<.001	.004	3	1
LARGE_INTESTINE	BPIFA1 →	+0.300	+4.273	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	MS4A18 →	+0.028	+4.095	<.001	.009	3	1
LARGE_INTESTINE	F11 →	+0.073	+4.467	<.001	.004	3	1
BLOOD_Lymphoma	OR11G2 →	+0.016	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PCDH11Y by GLA expression — URINARY_TRACT

Explore this box plot interactively →