Across TCGA pan-cancer cohorts, GKN2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GKN2 data layer compared with 20 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GKN2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GKN2 expression acts as an unfavorable survival marker.

LUAD, BLCA, and UCEC are the cancer types where GKN2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.251	0.788	.012	6	view →
BLCA	DFS	Median	All	0.194	0.511	.038	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: GKN2 tumor-vs-normal RNA expression · all GKN2 data types