Across TCGA pan-cancer cohorts, GKN2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GKN2 data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GKN2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GKN2 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC and LUAD are the cancer types where GKN2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.683	0.251	.005	25	view →
LUAD	DFS	Tertile	II,III,IV	0.764	0.980	.018	11	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: GKN2 tumor-vs-normal RNA expression · all GKN2 data types