Across TCGA patient cohorts, GKN2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GKN2-associated genes across cancer lineages are FOXO3a, MEK1, and PDCD4. Each is linked with GKN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GKN2-to-partner and partner-to-GKN2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GKN2→partner) and Y-score (partner→GKN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	+0.172	+2.351	<.001	.018	3	1
UCEC	MEK1 →	+0.478	+3.459	.009	.005	3	1
UCEC	PDCD4 →	-0.728	-3.160	.002	.019	3	1
UCEC	PKC-b-II_pS660 →	-0.316	-3.000	.022	.036	3	1
UCEC	ATM →	-0.511	-2.321	.024	.035	3	1
UCEC	JNK2 →	+0.362	+3.459	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

GKN2 survival (RNA) · tumor vs normal (RNA) · all GKN2 data types