GKN1

Across TCGA pan-cancer cohorts, GKN1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GKN1 data layer compared with 18 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher GKN1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GKN1 expression acts as an unfavorable survival marker.

SKCM and COAD are the cancer types where GKN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.175	0.760	<.001	25	view →
COAD	OS	Median	All	0.107	0.678	<.001	17	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

GKN1–SKCM (DFS)

Open the SKCM breakdown →