GKN1

Across TCGA pan-cancer cohorts, GKN1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GKN1 data layer compared with 18 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GKN1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GKN1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC and CCRCC are the cancer types where GKN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.604	0.277	.020	8	view →
CCRCC	DFS	Quartile	All	0.935	0.573	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

GKN1–PDAC (DFS)

Open the PDAC breakdown →