GKN1

Across TCGA patient cohorts, GKN1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GKN1-associated genes across cancer lineages are Ku80, p90 RSK, and Shc_pY317. Each is linked with GKN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GKN1-to-partner and partner-to-GKN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by GKN1-low versus GKN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GKN1→partner) and Y-score (partner→GKN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.306	+3.183	.018	.010	3	1
UCEC	p90 RSK →	+0.260	+3.009	.013	.019	3	1
UCEC	Shc_pY317 →	-0.215	-3.169	.010	.020	3	1
UCEC	PDCD4 →	-0.811	-3.169	.001	.020	2	1
UCEC	4E-BP1 →	+0.305	+3.169	.040	.020	2	1
UCEC	JNK_pT183_Y185 →	-0.243	-3.156	.008	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Ku80 by GKN1 expression — UCEC

Explore this box plot interactively →