GKN1

Across TCGA cell cohorts, GKN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 895 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GKN1-associated GO terms across cancer lineages are Negative regulation of calcium-mediated signaling, Blood coagulation, fibrin clot formation, and Cell-substrate adhesion. Each is linked with GKN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both GKN1-to-partner and partner-to-GKN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium-mediated signaling grouped by GKN1-low versus GKN1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GKN1→partner) and Y-score (partner→GKN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of calcium-mediated signaling →	+0.082	+0.026	.002	.009	3	5
PANCREAS	Blood coagulation, fibrin clot formation →	+0.214	+0.711	.001	.005	3	5
SOFT_TISSUE	Cell-substrate adhesion →	+0.100	+0.053	<.001	.003	3	4
STOMACH	Substrate adhesion-dependent cell spreading →	+0.094	+0.234	.004	.004	3	4
SOFT_TISSUE	Indole-containing compound metabolic process →	-0.131	-0.045	<.001	.003	3	4
URINARY_TRACT	L-tryptophan metabolic process →	-0.159	-4.074	.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 895 associations by consensus.

Negative regulation of calcium-mediated signaling by GKN1 expression — LARGE_INTESTINE

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