GKAP1

Across TCGA pan-cancer cohorts, GKAP1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GKAP1 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GKAP1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GKAP1 expression acts as an unfavorable survival marker.

HNSC, COAD, and READ are the cancer types where GKAP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.122	0.710	.001	39	view →
COAD	DFS	Median	All	0.148	0.692	<.001	26	view →
READ	OS	Median	II,III,IV	0.054	0.934	<.001	24	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	III,IV	0.088	0.613	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GKAP1–HNSC (DFS)

Open the HNSC breakdown →