GKAP1

Across TCGA pan-cancer cohorts, GKAP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GKAP1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher GKAP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GKAP1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

GBM, LUAD, and HNSC are the cancer types where GKAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.912	0.639	.002	12	view →
LUAD	DFS	Quartile	All	0.870	0.608	.014	8	view →
HNSC	OS	Tertile	III,IV	0.968	0.499	.036	5	view →
LSCC	OS	Median	All	0.931	1.000	.018	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GKAP1–GBM (DFS)

Open the GBM breakdown →